Assuntos
Doenças do Cabelo/diagnóstico por imagem , Pilomatrixoma/diagnóstico por imagem , Neoplasias Cutâneas/diagnóstico por imagem , Ultrassonografia/métodos , Criança , Feminino , Doenças do Cabelo/patologia , Doenças do Cabelo/cirurgia , Humanos , Lactente , Pilomatrixoma/patologia , Pilomatrixoma/cirurgia , Pele/patologia , Neoplasias Cutâneas/patologia , Neoplasias Cutâneas/cirurgiaRESUMO
Juvenile xanthogranuloma is a benign, self-healing disorder with characteristic lesions mainly involving the skin. Although most patients with juvenile xanthogranuloma have only cutaneous symptoms, recent articles have documented extracutaneous manifestations: systemic involvement of many organs has been reported and there is a known association between juvenile xanthogranuloma and childhood leukemia, most commonly juvenile chronic myelogenous leukemia. This case provides further corroboration, that in rare instances, juvenile xanthogranuloma may be associated with hematologic malignancies.
Assuntos
Leucemia-Linfoma Linfoblástico de Células Precursoras/complicações , Xantogranuloma Juvenil/complicações , Pré-Escolar , Humanos , Masculino , Recidiva , Xantogranuloma Juvenil/patologiaAssuntos
Herpes Simples/diagnóstico , Pênfigo/diagnóstico , Pênfigo/tratamento farmacológico , Administração Tópica , Betametasona/uso terapêutico , Biópsia por Agulha , Diagnóstico Diferencial , Quimioterapia Combinada , Feminino , Seguimentos , Herpes Simples/tratamento farmacológico , Herpes Simples/patologia , Humanos , Imuno-Histoquímica , Recém-Nascido , Mupirocina/uso terapêutico , Pênfigo/patologia , Índice de Gravidade de Doença , Resultado do TratamentoRESUMO
Benign lymphangiomatous papules of the skin are considered reactive lymphatic proliferations either caused by disruption of the lymphatic flow or tissue damage produced by operation or radiation therapy. We report a 72-year-old woman with umbilical papules and vesicle-like lesions that led to the diagnosis of a large ovarian fibroma. Histologic study revealed dilated lymphatic spaces manifesting an anastomosing and branched pattern in the papillary and reticular dermis dissecting collagen bundles. The vessels were lined by plump endothelial cells with foci of intravascular papillary endothelial cell hyperplasia. After the ovarian fibroma was removed by laparotomy, umbilical lesions almost disappeared, leaving small flesh-colored papules. A periumbilical dermatosis may herald certain intra-abdominal diseases including those of neoplastic derivation. A heightened awareness of this association may lead to an early diagnosis with a potential for improved patient outcome. Benign lymphangiomatous papules have not been previously described in association with an untreated tumor, without previous operation or radiotherapy. This case advocates for disruption of the lymphatic drainage as the probable pathogenetic mechanism.